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United States of America Patent

APP PUB NO 20150273057A1
SERIAL NO

14437231

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Abstract

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A novel combination comprising a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and/or the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and an EGFR inhibitor suitably cetuximab (Erbitux) or erlotinib; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf and/or EGFR is beneficial, eg. cancer.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS PHARMA AGLICHTSTRASSE 35 4056 BASEL 4056

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Greshock, Joel Collegeville, US 3 3
Hoos, Axel Collegeville, US 15 23

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