BIOASSAY SYSTEM AND METHOD FOR DETECTING ANALYTES IN BODY FLUIDS
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United States of America Patent
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Sep 24, 2015
app pub date -
Mar 20, 2015
filing date -
Mar 24, 2014
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Abstract
A bioserisor platform is configured with upconverting nanoparticles on the surface of a resonant grating structure with enhanced sensitivity. The grating structure is illuminated with a light beam at one of its resonance modes to form a strong evanescent field at the surface and used for high sensitivity assays. The strong evanescent field triggers the upconverting nanoparticles to generate enhanced and localized emission on the grating surface, with lower background and lower auto-fluorescence from the grating substrate. This leads to improved performance in detecting analytes in bioassays.
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