Method for activating Oct4 for induction of pluripotent stem cells

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United States of America Patent

PATENT NO 9783786
APP PUB NO 20150267173A1
SERIAL NO

14411506

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Abstract

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The invention relates to a method for inducing pluripotent stem cells, wherein a mammalian cell is contacted with a compound characterized by a general formula 1 wherein R1 is (CH2)mE, with E being CCH or CN and m being 0, 1, or 2, and R2 is selected from F, CI, Br, OR3 and R3, with R3 being selected from H, (CHyF2-y)n CHXF3-X, with n=0 or 1. The invention further relates to stem cells obtained by the method of the invention, and culture media comprising the compound of the invention.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITÄTSKLINIKUM JENA07747 JENA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheng, Xinlai Kaiserslautern, DE 2 0
Mrowka, Ralf Jena, DE 3 0
Wolf, Gunter Jena, DE 44 540
Wolfl, Stefan Dossenheim, DE 4 27

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