RORγ modulators

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United States of America Patent

PATENT NO 10035790
SERIAL NO

14436355

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Abstract

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Described are RORy modulators of the formula (I), and N-oxides thereof, and pharmaceutically acceptable salts thereof, and solvates and hydrates thereof, wherein R1, R2, R3, R4, R5, R6, Ra, x, y, L, G, Z, the bond denoted by “q”, the ring system denoted by “A” and the ring system denoted by “B” are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORy activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORy activity, for example, autoimmune and/or inflammatory disorders.

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Patent Owner(s)

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EXELIXIS INC1851 HARBOR BAY PARKWAY ALAMEDA CA 94502

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bannen, Lynne Canne Pacifica, US 38 934
Dhar, T G Murali Princeton, US 72 363
Jeong, Joon Won Belmont, US 10 74
Kim, Byung Gyu Daejeon, KR 30 197
Koltun, Elena S Foster City, US 57 375
Ma, Sunghoon Foster City, US 15 316
Wang, Yong Foster City, US 1107 9670
Xu, Wei Danville, US 934 8439

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