MODULATION OF PODOPLANIN MEDIATED PLATELET ACTIVATION
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United States of America Patent
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Sep 17, 2015
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Sep 12, 2013
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Sep 12, 2012
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The present invention relates generally to the use of modulators of podoplanin (PDPN) mediated platelet activation. For example, an agonist or mimic of podoplanin (PDPN)/C-type lectin-like receptor 2 (CLEC-2) signaling may be used to inhibit vascular leakage or promote vascular integrity. Alternatively, an antagonist of podoplanin (PDPN)/C-type lectin-like receptor 2 (CLEC-2) signaling may be used to inhibit platelet activation.
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