TRAINING METHODS FOR IMPROVED ASSAYING OF PAIN IN CLINICAL TRIAL SUBJECTS
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United States of America Patent
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Sep 3, 2015
app pub date -
Oct 11, 2013
filing date -
Oct 12, 2012
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Provided are methods for training subjects to report pain, and for identifying accurate pain reporting subjects prior to or subsequent to training. The methods of the invention generally involve: determining the reported pain threshold and tolerance levels of the subject in response to an evoked pain stimulus; determining the reported pain of the subject in response to a natural index pain using a standard pain reporting scale; determining the response profile of the subject to noxious stimuli using a standard pain reporting scale, wherein the noxious stimuli intensity are between the pain threshold and tolerance levels of the subject; and determining the pain reporting accuracy and/or reliability of the subject.
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