METAL NANOPARTICLE-APTAMER CONJUGATES FOR DETECTION OF SMALL MOLECULES AND IN-THE-FIELD USE THEREOF
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United States of America Patent
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Sep 3, 2015
app pub date -
Feb 28, 2014
filing date -
Feb 28, 2014
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Abstract
A method of detecting a presence of an analyte in a sample. The method includes selecting an aptamer selective to the analyte and binding the aptamer to a nanoparticle. The nanoparticles having a free state are perceived as a first color and an aggregate state are perceived as a second color. The sample is introduced to the nanoparticle-bound aptamers, and aggregation of the nanoparticles is promoted. A colorimetric change is analyzed, wherein the aggregate state of the nanoparticles is achieved in the presence of the analyte in the sample.
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