MICROSOMES IRREVERSIBLY INHIBITED FOR CYP450 THEIR USES IN THEPHENOTYPING OF ENZYMATIC METABOLIC PATHWAYS
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United States of America Patent
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Issued Date -
Sep 3, 2015
app pub date -
Dec 5, 2014
filing date -
Dec 5, 2013
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Abandoned
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Abstract
Method of preparing isolated microsomes comprising an irreversibly inhibited cytochrome P450 (CYP450). Isolated microsome characterised in that a cytochrome P450 thereof is irreversibly inhibited by a non-reversible inhibitor. Use of isolated microsomes according to the Invention in a method of phenotyping enzymatic reactions of a drug candidate.
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