Piggy back delivery of nucleic acids into organisms
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United States of America Patent
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Sep 27, 2016
Grant Date -
Sep 3, 2015
app pub date -
May 18, 2015
filing date -
Mar 2, 2012
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Abstract
The present invention includes nucleic acid hybrid molecules capable of entering cells comprising at least one vivo-morpholino oligonucleotide (vivo-MO) comprising a guanidine-rich head conjugated to the 5′ end, and at least one standard oligonucleotide comprising a gene-specific sequence and a standard oligonucleotide pairing sequence, wherein the standard oligonucleotide is bound to the vivo-morpholino oligonucleotide through base pairing to form a hybrid and wherein the vivo-morpholino oligonucleotide pairing sequence is complementary to the standard oligonucleotide pairing sequence.
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