Generation of airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres
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Jun 5, 2018
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Jul 24, 2013
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Jul 24, 2012
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Abstract
Embodiments of the present invention are directed to various methods for generating airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres, and to populations of cells made using the methods. The airway and lung progenitors and epithelial cells can be used as a model to study diseases that primarily affect airway epithelial cells, and to study human lung development. Methods are also provided for drug screening. Anterior foregut spheres can be used as a model for lung fibrosis.
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