Tangential flow perfusion system
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
May 30, 2017
Grant Date -
Sep 3, 2015
app pub date -
Sep 25, 2013
filing date -
Sep 27, 2012
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The invention discloses a system for perfusion culture of cells which comprises: a bioreactor; a filter unit with a retentate inlet end, a retentate outlet end and a permeate outlet port; a reciprocating pump fluidically connected to the retentate inlet end, with the retentate inlet end fluidically connected to the bioreactor via an inlet check valve arranged to allow flow in the direction from the bioreactor to the retentate inlet end and to block flow in the reverse direction, and where the retentate outlet end is fluidically connected to the bioreactor via an outlet check valve arranged to allow flow in the direction from the retentate outlet end to the bioreactor and to block flow in the reverse direction; and where the inlet and outlet check valves are each fluidically connected to a tubing branch point, which is further connected to the bioreactor via a length of tubing. In an alternative embodiment, each of said inlet and outlet check valves is fluidically connected to the bioreactor via separate lengths of tubing. The invention further discloses a pre-sterilized system for perfusion culture of cells which comprises: a bioreactor; a reciprocating pump and a filter unit fluidically connected to the reciprocating pump and fluidically connected to the bioreactor via at least one aseptic connector.
First Claim
Other Claims data not available
Family
International Classification(s)
- 2013 Application Filing Year
- C12N Class
- 5078 Applications Filed
- 4006 Patents Issued To-Date
- 78.89 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 5 Citation Count
- C12N Class
- 53.39 % this patent is cited more than
- 8 Age
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Nov 30, 2024 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Nov 30, 2028 |
