Parathyroid hormone, insulin, and related peptides conjugated to bone targeting moieties and methods and making and using thereof
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United States of America Patent
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Aug 1, 2017
Grant Date -
Sep 3, 2015
app pub date -
Aug 28, 2013
filing date -
Aug 28, 2012
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Abstract
Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate de novo bone turnover and stimulate bone fracture repair.
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