Heterodimers of IL-15 and IL-15R alpha to increase thymic output and to treat lymphopenia

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United States of America Patent

PATENT NO 9975937
SERIAL NO

14512913

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Abstract

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The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with supraphysiological levels of interleukin (IL)-15. The present invention also provides methods for preventing, alleviating, reducing, and/or inhibiting lymphopenia or peripheral depletion of lymphocytes in a patient in need thereof by administering to the patient IL-15.

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Patent Owner(s)

Patent OwnerAddress
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES4770 BUFORD HIGHWAY MS K-79 CENTERS FOR DISEASE CONTROL AND PREVENTION TECHNOLOGY TRANSFER OFFICE ATLANTA GA 30341

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bergamaschi, Cristina Frederick, US 7 39
Felber, Barbara K Rockville, US 33 638
Pavlakis, George N Rockville, US 46 923
Valentin, Antonio Frederick, US 7 39

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