Methods and compositions for specific modulation of MCL-1
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United States of America Patent
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Nov 29, 2016
Grant Date -
Sep 3, 2015
app pub date -
May 15, 2015
filing date -
Dec 9, 2008
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Abstract
A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death.
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