Combinations of a caspase inhibitor and an antiviral agent

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United States of America Patent

PATENT NO 9833492
SERIAL NO

14713477

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Abstract

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A compound is provided which has a structure I: A-B-C and a method for administering the compound is also provided for use in the prophylaxis and/or treatment of a viral infection, and in particular for preventing and/or inhibiting viral replication, in which A is a quinoline or quinoline-like group, B is a sole amino acid or a peptide or polypeptide having a given amino acid sequence, and C is an O-phenoxy group. According to one embodiment, the compound is a protease inhibitor such as a caspase inhibitor, and the inhibitor can be Q-VD-OPh (N-(2-(quinolyl)valylaspartyl-(2,6-difluorophenoxyl)methyl ketone), optionally in an O-methylated form. Antiviral compositions and kits are also provided.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITÉ PARIS-SACLAY91190 GIF-SUR-YVETTE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Estaquier, Jerome Montmorency, FR 2 0
Laforge, Mireille Maisons Alfort, FR 6 0
Senik, Anna Paris, FR 3 0

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