Use of Mutant Herpes Simplex Virus-2 for Cancer Therapy
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United States of America Patent
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Issued Date -
Sep 3, 2015
app pub date -
Jan 21, 2015
filing date -
Jun 23, 2005
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Abstract
The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 comprises a modified/mutated ICP10 polynucleotide encoding a polypeptide having ribonucleotide reductase activity and lacking protein kinase activity.
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