Methods and compositions for site-specific labeling of peptides and proteins
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United States of America Patent
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Jan 31, 2017
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app pub date -
Sep 5, 2013
filing date -
Sep 7, 2012
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Abstract
Methods and compositions are provided for covalently linking a chemical species to a recombinant or synthetic polypeptide. The methods involve the reaction of a thioester-comprising polypeptide with a reagent comprising a reactive amino-thiol group connected to the chemical species which is to be covalently linked to the polypeptide, via a linker. Such chemical species can be a functional group, a label or tag molecule, a biological molecule, a ligand, or a solid support. Efficient and catalyst-free methods for C-terminal protein labeling are also provided. The methods expand current capabilities in the area of protein functionalization, providing useful and complementary tools for the isolation, detection, characterization, and analysis of proteins in a variety of in vitro and in vivo applications.
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International Classification(s)
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- C12P:FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESI....
- C08G:MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN B....
- C07D:HETEROCYCLIC COMPOUNDS
- C12N:MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- C09B:ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PROD....
- C40B:COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL ....
- C08L:COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C07K:PEPTIDES
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