IRHOM2 INHIBITION FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS

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United States of America Patent

APP PUB NO 20150241429A1
SERIAL NO

14427185

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed are methods for treating a subject with a Complement mediated (e.g., C5a mediated) disease or an immune complex mediated disease. The method comprises the step of administering to the subject an effective amount of an agent that decreases the biological activity of iRhom2 or an agent that modulates formation of a complex between iRhom2 and TACE. Also disclosed are assays for identifying such agents.

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Patent Owner(s)

Patent OwnerAddress
HOSPITAL FOR SPECIAL SURGERY535 EAST 70TH STREET NEW YORK NY 10021

International Classification(s)

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  • 2013 Application Filing Year
  • C12Q Class
  • 2617 Applications Filed
  • 2019 Patents Issued To-Date
  • 77.15 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blobel, Carl New York, US 7 0
Issuree, Priya New York, US 1 0
Mak, Tak Wah Toronto, CA 11 45
Maretzky, Thorsten New York, US 2 0
McIlwain, David Toronto, CA 2 0
Salmon, Jane New York, US 1 0

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges1327176424995462115376501 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 90100 +01002003004005006007008009001000110012001300140015001600170018001900

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