Detection and Quantification of Hydroxymethylated Nucleotides in a Polynucleotide Preparation

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United States of America Patent

APP PUB NO 20150240310A1
SERIAL NO

14685966

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Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmNs.

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NEW ENGLAND BIOLABS INC240 COUNTY ROAD IPSWICH MA 01938

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bitinaite, Jurate Rowley, US 8 132
Chin, Hang-Gyeong South Hamilton, US 7 108
Cohen-Karni, Devora Cambridge, US 2 47
Noren, Christopher Boxford, US 5 85
Pradhan, Sriharsa Wenham, US 19 176
Raleigh, Elisabeth A Somerville, US 9 150
Roberts, Richard J Wenham, US 36 369
Vaisvila, Romualdas Ipswich, US 20 238
Wilson, Geoffrey South Hamilton, US 26 491
Zheng, Yu Topsfield, US 445 9357

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