Detection and Quantification of Hydroxymethylated Nucleotides in a Polynucleotide Preparation

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United States of America Patent

APP PUB NO 20150240310A1
SERIAL NO

14685966

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmNs.

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NEW ENGLAND BIOLABS INC240 COUNTY ROAD IPSWICH MA 01938

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  • 2015 Application Filing Year
  • C12Q Class
  • 3483 Applications Filed
  • 2244 Patents Issued To-Date
  • 64.43 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bitinaite, Jurate Rowley, US 8 132
Chin, Hang-Gyeong South Hamilton, US 7 108
Cohen-Karni, Devora Cambridge, US 2 47
Noren, Christopher Boxford, US 5 85
Pradhan, Sriharsa Wenham, US 19 176
Raleigh, Elisabeth A Somerville, US 9 150
Roberts, Richard J Wenham, US 36 369
Vaisvila, Romualdas Ipswich, US 20 238
Wilson, Geoffrey South Hamilton, US 26 491
Zheng, Yu Topsfield, US 445 9357

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  • 14 Citation Count
  • C12Q Class
  • 87.37 % this patent is cited more than
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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges1327176424995462115376501 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 90100 +01002003004005006007008009001000110012001300140015001600170018001900

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