Blood-brain Barrier Epitopes and Uses Thereof
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United States of America Patent
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Issued Date -
Aug 27, 2015
app pub date -
Feb 27, 2015
filing date -
Sep 27, 2005
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Abstract
The invention features a method of identifying an agent and generating an antibody that can cross the blood brain barrier, through the use of novel antigen isoforms of transmembrane domain protein 30A (TMEM30A). This is useful in establishing mechanisms of transmigration across the blood-brain barrier. These antigens are enriched in brain endothelium compared to other endothelial cells and may have better selectivity and capacity for brain delivery compared to transferrin and insulin receptors. One antigen is TMEM30A.
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