CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF
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United States of America Patent
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app pub date -
Oct 15, 2014
filing date -
Oct 15, 2013
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Abstract
Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain (TID). The switch may further comprise a linker. Further disclosed herein are methods of using the switches for the treatment of one or more conditions or diseases in a subject in need thereof.
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