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• 15 United States
• 10 France
• 8 Japan
• 7 China
• 5 Korea
• 2 Other

Patent Owner(s)

Patent Owner	Address
EMORY UNIVERSITY	ATLANTA GA

International Classification(s)

• A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
• C12N:MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF
• C07K:PEPTIDES

• 2014 Application Filing Year
• A61K Class
• 14144 Applications Filed
• 11600 Patents Issued To-Date
• 82.02 % Issued To-Date

Inventor(s)

Inventor Name	Address	# of filed Patents	Total Citations
EARL, PATRICIA	Chevy Chase, US	9	47
# of filed Patents : 9 Total Citations : 47
MOSS, BERNARD	Bethesda, US	51	625
# of filed Patents : 51 Total Citations : 625
ROBINSON, HARRIET L	Atlanta, US	19	261
# of filed Patents : 19 Total Citations : 261
WYATT, LINDA	Rockville, US	8	73
# of filed Patents : 8 Total Citations : 73

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Full Text

US Patent Application No: 2013/0281,513

siRNA FOR INHIBITION OF Hif1alpha EXPRESSION AND ANTICANCER COMPOSITION CONTAINING THE SAME

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Abstract

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Disclosed are small interfering RNA (siRNA) that complementarily binds to a base sequence of Hif1α mRNA transcript, thereby inhibiting expression of Hif1α without inducing immune responses, and a use of the siRNA for prevention and/or treatment of cancer. Since Hif1α is commonly overexpressed in almost all cancer cells, the siRNA that complementarily binds to Hif1α-encoding mRNA may inhibit expression of Hif1α through RNA-mediated interference (RNAi), thereby inhibiting proliferation and metastasis of cancer cells, and thus, the siRNA may be useful as an anticancer agent.

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Description

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