INJECTABLE STERILE AQUEOUS FORMULATION BASED ON CROSSLINKED HYALURONIC ACID AND ON HYDROXYAPATITE, FOR THERAPEUTIC USE
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United States of America Patent
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Aug 27, 2015
app pub date -
Sep 24, 2013
filing date -
Oct 8, 2012
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Abstract
This invention relates to an absorbable sterile injectable aqueous formulation that is ready to use, used for therapeutic purposes as a cohesive particle-based viscoelastic gel containing i) cross-linked hyaluronic acid, or one of its salts, at a concentration between 1% and 4% (mass/volume), with the cross-linking that is performed making it possible to obtain a gel having a base of cross-linked hyaluronic acid having a so-called cohesive structure, and ii) hydroxyapatite. at a concentration between 10% and 70% (mass/volume), said hydroxyapatite being in the form of particles having an average size less than or equal to 650 μm; with the said sterile injectable aqueous formulation having viscoelastic properties such that Tan δ at a frequency of 1 Hz is less than or equal to 0.60.
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