Mitochondrial-nuclear exchanged cells, tissues, organs and animals
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United States of America Patent
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Mar 14, 2017
Grant Date -
Aug 20, 2015
app pub date -
Apr 27, 2015
filing date -
Jun 27, 2008
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Abstract
Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof.
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