HIGH AFFINITY NY-ESO T CELL RECEPTORS
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United States of America Patent
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app pub date -
Apr 17, 2015
filing date -
May 19, 2004
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Abstract
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
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