Process for the preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline
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United States of America Patent
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Dec 1, 2015
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Aug 13, 2015
app pub date -
Sep 6, 2013
filing date -
Sep 6, 2012
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Abstract
Disclosed herein a novel, process for the preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline [(S)-1]. Particularly, the invention relates to the synthesis of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline with excellent selectivity starting from commercially available enantiopure (R)-epichlorohydrin [(R)-2] via formation of aziridine intermediate [(S)-4].
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