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Abstract

A method for screening patients with a cancer comprising i) determining in a tumor sample obtained from a patient an expression level ELA₁-ELA_n of one or several genes GA₁-GA_n representative of human adaptive immune response and an expression level ELI₁-ELI_n of one or several genes Gl₁-GI_n representative of human immunosuppressive response, ii) comparing the expression levels ELA₁-ELA_n and ELI₁-ELI_n determined at step i) with predetermined reference values ELRA₁-ELRA_n and ELRI₁-ELRI_n selected such as said predetermined reference values separate a panel of patients with a cancer into two groupings according to the expression level of said genes and to survival of patients according to Kaplan Meier curves analyses and associated logrank p values iii) concluding whether the patient has a good (level higher than the predetermined reference value) or a bad (level lower than the predetermined reference value) adaptive immune response and a good or a bad immunosuppressive response, optionally further comprising a step of concluding that a patient would or would not advantageously receive an antitumoral treatment, a kit comprising components for implementing step i) and a chemotherapeutic agent, an immunotherapeutic agent or a radiotherapeutic agent for use in the treatment of a cancer patient who is considered as responder to antitumoral treatment according to the method.

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First Claim