ASSAY AND METHOD FOR THE IDENTIFICATION OF INDIVIDUAL RESPONSIVENESS TO IMMUNOGLOBULIN THERAPY
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United States of America Patent
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Issued Date -
Jul 30, 2015
app pub date -
Jun 6, 2012
filing date -
Jun 7, 2011
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Abandoned
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Abstract
A method for determining the likelihood of response of an individual, suffering from a disease, towards immunoglobulin therapy has the steps of
- providing a sample containing B- and T-lymphocytes, natural killer cells, invariant T-cells and monocytes of the individual;genotyping of at least one of the polynucleotides of an ADAMTS9-Intron; a KLHDC8A-Intron or of a flanking region of the CD14 gene, andawarding the value of 1 for the homozygous Single Nucleotide Polymorphism combinations, which suggests that the blood sample stems from a person which will not respond to immunoglobulin treatment,while awarding the value of 0 for SNP not meeting that criteria, which suggests that the blood sample stems from a person which will respond to immunoglobulin treatment.
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