RECOMBINANT MICROORGANISMS AND METHODS OF USE THEREOF

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United States of America Patent

APP PUB NO 20150210987A1
SERIAL NO

14609420

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Abstract

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The invention provides a carboxydotrophic acetogenic bacterium comprising a disrupting mutation in a lactate biosynthesis pathway enzyme and a method of producing a product by culturing the bacterium in the presence of a substrate comprising carbon monoxide. Preferably, the lactate biosynthesis pathway enzyme is lactate dehydrogenase (LDH) or another enzyme that converts pyruvate to lactate, wherein the disrupting mutation reduces or eliminates the expression or activity of the enzyme such that the bacterium produces a reduced amount of lactate or no lactate.

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Patent Owner(s)

Patent OwnerAddress
LANZATECH NZ INC8045 LAMON AVENUE SUITE 400 SKOKIE IL 60077

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Al-Sinawi, Bakir Sydney, AU 13 52
De, Tissera Sashini Auckland, NZ 2 4
Koepke, Michael Skokie, US 79 227
Nagaraju, Shilpa Skokie, US 9 27

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