DUAL-TARGETING DRUG CARRIER AND METHOD FOR FABRICATING THE SAME
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United States of America Patent
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Issued Date -
Jul 30, 2015
app pub date -
May 7, 2014
filing date -
Jan 24, 2014
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Abandoned
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Abstract
The present invention discloses a dual-targeting drug carrier and a method for fabricating the same, wherein WGA- and FA-modified MPEG-PLA nanoparticles of the carrier enable the anticancer drugs encapsulated thereinside to pass through BBB and target human glioblastoma cells. The dual-target drug carrier is fabricated in an emulsion-solvent evaporation technology and verified with an in-vitro BBB model formed of HBMECs, HAs and HBVPs. The present invention can increase the permeability of the in-vitro BBB model to the dual-target drug carrier and promote the glioblastoma-inhibition effect. Therefore, the present invention would contribute to the clinical therapy of brain cancers substantially in the future.
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