LIPOSOMAL COMPOSITIONS OF EPOXYKETONE-BASED PROTEASOME INHIBITORS
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United States of America Patent
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Issued Date -
N/A
app pub date -
Jul 17, 2013
filing date -
Jul 18, 2012
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions provide prolonged drug exposure (relative to non-liposomal compositions comprising peptide epoxyketone compounds) without significantly affecting biodistribution of the drug. Tolerability of peptide epoxyketone compounds was also enhanced when formulated in the liposomal compositions.
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