Endostatin mutants with mutations at ATP binding sites

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United States of America Patent

PATENT NO 10647968
APP PUB NO 20140308263A1
SERIAL NO

14343694

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Abstract

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The present invention discloses a new anti-tumor medicament comprising a mutant of endostatin. The mutant comprises a mutation in the ATP-binding site of endostatin and has a decreased ATPase activity and an increased anti-angiogenesis activity.

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Patent Owner(s)

Patent OwnerAddress
TSINGHUA UNIVERSITY100084 NO 1 TSINGHUA YUAN BEIJING HAIDIAN DISTRICT BEIJING CITY BEIJING CITY 100084

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Guodong Beijing, CN 21 31
Chen, Yang Beijing, CN 340 2375
Fu, Yan Beijing, CN 95 1100
Liu, Peng Beijing, CN 833 6111
Lu, Xinan Beijing, CN 11 8
Luo, Yongzhang Beijing, CN 29 57
Zhou, Daifu Beijing, CN 4 3

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