Compounds for improved stem cell differentiation into hepatocytes
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United States of America Patent
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May 10, 2016
Grant Date -
Jul 16, 2015
app pub date -
Mar 12, 2014
filing date -
Mar 15, 2013
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Abstract
The invention relates to the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein R1-R11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are useful in differentiating stem cells into more mature or adult-like hepatocytes for use as drug screening platforms and in disease modeling applications.
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