SYSTEM AND METHOD FOR USING ULTRASOUND-STIMULATED MICROBUBBLE EXPOSURES TO INDUCE CERAMIDE ACCUMULATION IN ENDOTHELIAL AND TUMOR CELLS

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United States of America Patent

APP PUB NO 20150196638A1
SERIAL NO

14413623

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Abstract

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A system and method for using ultrasound and a microbubble agent to induce ceramide accumulation in a target region including a population of cells associated with a tumor. An ultrasound system is directed to expose a target region in a patient, to which a microbubble agent has been provided, to an ultrasound exposure sufficient to alter gene expressions in cells in the target region so as to induce an accumulation of ceramide in the cells.

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SUNNYBROOK HEALTH SCIENCES CENTRETORONTO ON M4N 3M5

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  • 2013 Application Filing Year
  • A61K Class
  • 12711 Applications Filed
  • 11051 Patents Issued To-Date
  • 86.95 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Almahrouki, Azza Scarborough, CA 1 6
Burns, Peter Nicholas Toronto, CA 1 6
Czarnota, Gregory J Oakville, CA 7 49
Giles, Anoja North York, CA 1 6
Karshafian, Raffi Richmond Hill, CA 4 14
Kim, Christina Toronto, CA 5 79
Tran, William Tyler Toronto, CA 2 8
Wong, Emily Toronto, CA 3 13

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  • 6 Citation Count
  • A61K Class
  • 31.06 % this patent is cited more than
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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges4055742610302931335621135761001 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0500100015002000250030003500400045005000550060006500700075008000

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