Metal Sensitive Mutants of Matrix Metalloproteases and uses thereof
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United States of America Patent
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Issued Date -
Aug 7, 2014
app pub date -
Jan 7, 2014
filing date -
Jan 7, 2013
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Abandoned
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Abstract
Provided herein are methods of using modified matrix metalloprotease (MMP) enzymes that exhibit regulated activity in the presence of calcium. The methods include conditionally controlling the activity of the MMPs through the use of calcium to treat fibrotic diseases or conditions involving a component of the extracellular matrix (ECM).
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