METHODS FOR DETERMINING WHETHER A CYTOMEGALOVIRUS INFECTION IN A TRANSPLANTED PATIENT IS SUCEPTIBLE TO INDUCE ALLOGRAFT REJECTION
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United States of America Patent
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Issued Date -
Jul 9, 2015
app pub date -
Jul 9, 2013
filing date -
Jul 10, 2012
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Abstract
The present invention relates to a method for determining whether a cytomegalovirus infection in a transplanted patient is susceptible to induce allograft rejection comprising detecting the presence of at least one HLA-E-restricted CD8 αβ T cell population displaying reactivity against peptides derived from the leader sequences of both HCMV-UL40 protein and allogeneic classical HLA-I molecules in a blood sample of the patient, wherein the presence of said populations indicated that the cytomegalovirus infection in the transplant patient is susceptible to induce allograft rejection.
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