DOMINANT NEGATIVE TRANSCRIPTION FACTOR FOR ANTAGONIZING ONCOGENIC TRANSCRIPTION FACTORS VIA MULTIMERIZATION
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United States of America Patent
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Issued Date -
Jul 9, 2015
app pub date -
Aug 27, 2013
filing date -
Aug 27, 2012
priority date (Note) -
Abandoned
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Abstract
The present invention teaches compositions, methods and kits for treating or preventing cancer in a subject by using a dominant negative transcription factor and/or a multimerization adaptor. The invention teaches that the dominant negative transcription factor can antagonize an oncogenic transcription activator and can cause cell cycle arrest and cell death in a cancer cell. The invention further teaches delivering the inventive compositions by a variety of mechanisms, including: transfection, a virus-based system, and using a protein-transduction-domain moiety fused to the inventive dominant negative transcription factor.
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