NOVEL METHOD FOR THE DIAGNOSIS OF ENDOMETRIOSIS
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United States of America Patent
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Jul 2, 2015
app pub date -
May 31, 2013
filing date -
May 31, 2012
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Abstract
The present invention relates to a method of diagnosing endometriosis, the method comprising (i) determining in a sample obtained from a subject: (a) the concentration of SMOH C16:1 and the ratio of the concentration of PCaa C36:2 to the concentration of PCae C34:2; (b) the concentration of PCae C30.0, the ratio of the concentration of PCaa C36.2 to the concentration of PCae C36.2 and the ratio of the concentration of Trp to the concentration of PCae C34.0; (c) the concentration of PCae C36.1, the ratio of the concentration of PCaa C36.2 to the concentration of PCae C36.2 and the ratio of the concentration of Trp to the concentration of PCae C34.0; (d) the concentration of SM C16.1, the ratio of the concentration of PCaa C36.2 to the concentration of PCae C36.2 and the ratio of the concentration of Trp to the concentration of PCae C34.0; (e) the concentration of SM C16.1, the ratio of the concentration of PCaa C36.2 to the concentration of PCae C36.2 and the ratio of the concentration of Arg to the concentration of PCae C34.2; (f) the concentration of SM C16:1, the ratio of the concentration of PCaa C36:2 to the concentration of PCae C36:2 and the ratio of the concentration of Trp to the concentration of PCae C34:2; and/or (g) the concentration of SMOH C22:2, the ratio of the concentration of PCaa C36:2 to the concentration of PCae C36:2 and the ratio of the concentration of Trp to the concentration of PCae C34:0 and (ii) comparing the values determined in (i) with values obtained from healthy subjects; wherein an increase in the concentration of the single metabolites in combination with a decrease in the ratio(s) as compared to values obtained from healthy subjects is indicative of endometriosis. The invention further relates to a kit comprising metabolite standards labelled with (a) stable isotope(s) or chemically similar compounds not naturally occurring in the human sample.
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