STABILIZED GP120
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United States of America Patent
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Issued Date -
Jul 2, 2015
app pub date -
Jun 17, 2013
filing date -
Jun 18, 2012
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Abstract
The present invention provides an isolated polypeptide comprising an HIV gp120 polypeptide or soluble gp140 polypeptide stabilized in a conformation which exposes both CD4-bound and CD4-binding site epitopes. The invention also provides immunogenic compositions and methods of treating and preventing infection with HIV.
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