NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

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United States of America Patent

SERIAL NO

14588804

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Abstract

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The present invention relates to a compound inhibiting Hsp90 and a pharmaceutical composition comprising the same as an active ingredient. The compounds represented by formula 1 and formula 2 of the present invention suppress the expression of Hsp90 so that they can inhibit the accumulation of HIF-1α, the Hsp90 client protein, and also efficiently inhibit the activation of VEGF. In addition, these compounds display low cytotoxicity, so that they can be effectively used as an active ingredient of an anti-cancer agent, a diabetic retinopathy treating agent, and an anti-arthritic agent.

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Patent Owner(s)

Patent OwnerAddress
SNU R&DB FOUNDATION1 GWANAK-RO GWANAK-GU SEOUL 08826

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
AN, Hongchan Seoul, KR 3 0
CHANG, Dong-Jo Seoul, KR 1 0
KIM, Kyu-Won Seoul, KR 14 49
KIM, Young-Myeong Gangwon-do, KR 8 14
LEE, Ho-Young Seoul, KR 131 1578
SUH, Young-Ger Seoul, KR 12 27

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges12662125286874713251301 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 80100 +010020030040050060070080090010001100120013001400150016001700180019002000210022002300

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