Importance

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Abstract

In alternative embodiments, the invention provides formulations, pharmaceutical compositions, devices and other products of manufacture comprising a therapeutically effective mixture of an insulin and a pramlintide, and methods for making and using them. For example, methods and compositions of the invention are used in the treatment or amelioration of a diabetes, a dementia or Alzheimer's disease, any abnormality of blood glucose control, an inability to control blood glucose, an elevation of fasting glucose or Impaired Fasting Glucose (IFG), an abnormality of tolerance to a glucose load or Impaired Glucose Tolerance (IGT), a hyperglycemia induced by an illness, a trauma, a medication administration or a form of metabolic, psychological or physical stress, or a hyperglycemia induced by steroids (steroid-induced diabetes), a latent autoimmune diabetes in adults (LADA), a postprandial or reactive Hypoglycemia or an insulin resistance, a PolyCystic Ovary Syndrome (PCOS), a ketoacidosis, a gestational diabetes, a hyperkalemia, a cancer or cachexia, a beta blocker overdose, or a jaundice. In alternative embodiments, the invention provides insulin pumps, devices, subcutaneous insulin infusion therapy devices, continuous subcutaneous insulin infusion therapy devices, infusion therapy devices, reservoirs, ampoules, vials, syringes, cartridges, disposable pen or jet injectors, prefilled pens or syringes or cartridges, cartridge or disposable pen or jet injectors, two chambered or multi-chambered pumps, syringes, cartridges or pens or jet injectors, or an artificial pancreas, comprising a formulation having an insulin:pramlintide ratio of the invention.

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First Claim