EX VIVO EXPANSION OF MYOGENIC STEM CELLS BY NOTCH ACTIVATION
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Jun 18, 2015
app pub date -
Jun 14, 2013
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Jun 14, 2012
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Abstract
Activating Notch signaling in cultured canine muscle derived cells inhibited myogenic differentiation, and increased the number of myogenic progenitor cells that were similar to quiescent or newly activated satellite cells. Importantly, cells expanded in the presence of Notch activation maintained engraftment potential, indicating the potential for therapeutic benefit. Activation of Notch signaling to inhibit myogenic differentiation in cultured human muscle-derived cells is also contemplated, for maintaining engraftment potential using such human cells in transplantation.
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