Retro Diels Alder Reaction as a Cleavable Linker in DNA/RNA Applications
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United States of America Patent
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Issued Date -
Jun 18, 2015
app pub date -
Apr 29, 2013
filing date -
May 21, 2012
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Abandoned
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Abstract
The invention provides a novel approach for reversibly conjugating an oligonucleotide, which includes obtaining an oligonucleotide labeled with a diene moiety and a target entity labeled with a dienophile moiety; heating the oligonucleotide labeled with the diene moiety and the target entity labeled with the dienophile moiety in a solution at a first temperature to effect Diels Alder reaction to produce a conjugate; and heating the conjugate to a second temperature to effect retro Diels Alder reaction to regenerate the oligonucleotide labeled with the diene moiety and the target entity labeled with the dienophile moiety.
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