CONVERSION OF CARDIOMYOCYTES INTO FAST CONDUCTING CARDIOMYOCYTES OR SLOW CONDUCTING NODAL CELLS
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United States of America Patent
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Issued Date -
Jun 18, 2015
app pub date -
May 17, 2013
filing date -
May 18, 2012
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Abstract
Tbx5 and Tbx3 were shown to be key determinants of regional identity in the AVCS. Various embodiments relate to increasing the amount of Tbx5 or Tbx3 in a cardiomyoctye whereby the cardiomycyte is converted to a fast conducting cardiomyocyte or a slow conducting nodal cell, respectively. Further embodiments employ the fast conducting cardiomyocytes and nodal cells in therapeutic methods and in methods for screening compounds for effect on these cell types.
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