Methods for Isolation and Decomposition of Mass Spectrometric Protein Signatures

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United States of America Patent

APP PUB NO 20150162175A1
SERIAL NO

14103527

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Abstract

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A method of analyzing a liquid mixture comprising protein or peptide molecules mixed with other molecules comprises: passing a portion of the mixture through a liquid chromatograph so as to elute the molecules; transferring the eluted portions of the molecules to an ion source of a mass spectrometer so as to generate ions comprising a plurality of ion species therefrom; transferring the generated ion species to a mass analyzer for detection thereby; generating a respective record of the intensity-versus-time variation of each of a plurality of the detected ion species; identifying and distinguishing a set of ion species corresponding to the ions generated from the eluted portion of the protein or peptide analyte molecules based on the records of the intensity-versus-time variation; and performing at least one additional operation on ions of one or more of the distinguished ion species generated from the protein or peptide analyte molecules.

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Patent Owner(s)

Patent OwnerAddress
THERMO FINNIGAN LLC355 RIVER OAKS PARKWAY SAN JOSE CA 95134

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
WRIGHT, David A Livermore, US 102 2062

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