METHOD FOR ATTENUATING A BACTERIUM OF THE MYCOBACTERIUM TUBERCULOSIS COMPLEX FOR PRODUCING A TUBERCULOSIS VACCINE
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Issued Date -
Jun 11, 2015
app pub date -
May 16, 2013
filing date -
May 21, 2012
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Abstract
The present invention concerns the use of a strain of a mycobacterium of the Mycobacterium tuberculosis complex in which a mspA gene capable of expressing a porin A of Mycobacterium smegmatis has been inserted, to produce a vaccine for the prevention of infection with a bacterium of the Mycobacterium tuberculosis complex in a host having eukaryote cells, preferably macrophages, the said strain of mycobacteria thus transformed having reduced growth in the said eukaryote cells.
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