MICROORGANISMS AND METHODS FOR THE PRODUCTION OF KETONES

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United States of America Patent

APP PUB NO 20150152445A1
SERIAL NO

14559881

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides a recombinant, acetogenic, carboxydotrophic bacterium that lacks secondary alcohol dehydrogenase or comprises an inactivated secondary alcohol dehydrogenase. The inactivated secondary alcohol dehydrogenase may be encoded by a secondary alcohol dehydrogenase gene comprising an inactivating mutation that reduces the ability of the bacterium to convert acetone to isopropanol and to convert methyl ethyl ketone to 2-butanol. Since a bacterium that lacks secondary alcohol dehydrogenase or comprises an inactivated secondary alcohol dehydrogenase accumulates carbonyl-containing compounds, the invention also provides a method of producing carbonyl-containing compounds, such as acetone and methyl ethyl ketone.

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Patent Owner(s)

Patent OwnerAddress
LANZATECH NZ INC8045 LAMON AVENUE SUITE 400 SKOKIE IL 60077

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Al-Sinawi, Bakir Sydney, AU 13 52
Hill, Ryan Edward Otago, NZ 11 30
Jensen, Rasmus Overgaard Skokie, US 7 19
Koepke, Michael Skokie, US 79 227
Mueller, Alexander Paul Skokie, US 13 39

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