Preparation of Technetium-99M Tricarbonyl Labeled Glycine Monomer or Oligomer Containing Probes That Have Biomolecules and Its Application as Imaging Complex-Composition

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United States of America Patent

APP PUB NO 20150151011A1
SERIAL NO

14399431

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Disclosed is a technetium-99m-labeled glycine oligomer associated with imaging probes for biomolecules of interest. The glycine oligomer can be readily synthesized in a single process using an automated peptide synthesizer. The technetium-99m tricarbonyl-labeled glycine oligomers can be useful as a radiotracer for gamma or SPECT imaging apparatus. The technetium-99m tricarbonyl-labeled glycine oligomers can be applied to various peptidyl biomolecules such as RGD peptide, somatostatin, neurotensin, etc., and exhibit rapid renal clearance without being excessively retained within the body.

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Patent OwnerAddress
KOREA ATOMIC ENERGY RESEARCH INSTITUTE111 DAEDEOK-DAERO 989BEON-GIL YUSEONG-GU DAEJEON 34057

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jang, Beom Su Daejeon, KR 8 15
Lee, Joo-Sang Daegu, KR 27 249
Park, Sang Hyun Jeollabuk-do, KR 240 2164
Rho, Jong-Kook Busan, KR 2 10

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