NUCLEIC ACID COMPLEX AND NUCLEIC ACID-POLYSACCHARIDE COMPLEX
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United States of America Patent
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Issued Date -
May 28, 2015
app pub date -
Jun 19, 2013
filing date -
Jun 20, 2012
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Abandoned
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Abstract
As a means for solving the problem of providing a nucleic acid conjugate that does not undergo degradation at a DNA-RNA bonding site even in vivo, provided is a nucleic acid conjugate comprising a single-stranded DNA and a double-stranded RNA, wherein the 3′ position of the 3′-terminal deoxyribonucleotide residue of the single-stranded DNA is bonded to the 5′ position of the 5′-terminal ribonucleotide residue of one of the ribonucleotide strands of the double-stranded RNA, and the hydroxyl group at the 2′ position of the 5′-terminal nucleotide of the ribonucleotide strand, which is bonded to the single-stranded DNA, is substituted with an alkoxy group or a halogen atom, and/or the phosphate diester group between the 3′ position of the first ribonucleotide bonded to the single-stranded DNA and the 5′ position of the adjacent ribonucleotide is substituted with any of phosphorothioate group, dithiophosphate diester group and trithiophosphate diester group.
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