N-CARBOXYALKYL-AURISTATIN AND USE THEREOF
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United States of America Patent
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app pub date -
Feb 5, 2015
filing date -
Sep 29, 2010
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Abstract
The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.
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